NIA Intervention Testing Program Solicits Recommendations for Compounds to Test for Anti-Aging Activity in Mice


Notice Number: NOT-AG-12-010

Key Dates

Release Date:  July 3, 2012
Deadline for Receipt Date:  September 21, 2012

Issued by

National Institute on Aging (NIA)

Purpose

The National Institute on Aging (NIA) Interventions Testing Program (ITP) was established to test compounds purported to extend lifespan and/or delay the onset of disease and disability.  The NIA ITP tests such compounds in mice, using a variety of measured endpoints to assess the efficacy of interventions.  Three funded awards perform the testing, one at the University of Michigan, one at the University of Texas Health Sciences Center-San Antonio, and one at the Jackson Laboratory.  It is anticipated that 3-5 compounds will be accepted for study in 2013.

The ITP is a collaborative effort between the study sites and external investigators who sponsor interventions for the study.  The sponsor’s role is to provide the rationale for investigating the intervention, make recommendations on the dose, route and timing for administration of the intervention, and propose assays and measurements to document the efficacy of the intervention.  The sponsor will have access to all data developed from the treated mice, will assist in analysis of the data and will be a co-author on resulting publications.  Sponsors' concepts for specific interventions are reviewed by an Access Panel and accepted interventions are prioritized by the ITP Steering Committee.

The NIA ITP is soliciting interventions from external investigators (sponsors) to enter the study in 2013.  The deadline for receipt is September 21, 2012. 

Information on the NIA ITP and guidelines for intervention and protocol development are posted at: http://www.nia.nih.gov/research/dab/interventions-testing-program-itp.

Inquiries

Please direct all inquiries to:

Nancy L. Nadon, Ph.D.
Chief, Biological Resources Branch
Division of Aging Biology
National Institute on Aging
7201 Wisconsin Ave., GW 2C231
Bethesda, Maryland 20892
Phone: 301-402-7744
FAX: 301-402-5997
nadonn@nia.nih.gov


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