POLICY ON SUPPORT OF LARGE-SCALE GENOME SEQUENCING PROJECTS Release Date: September 27, 1999 National Institute of Allergy and Infectious Diseases National Institute of Dental and Craniofacial Diseases The National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Dental and Craniofacial Research (NIDCR) will accept and consider for funding, under the conditions presented below, research applications for large-scale genome sequencing of microbial pathogens and invertebrate vectors of high priority to NIAID and NIDCR. Detailed information on the conditions can be found at following WWW sites: - For NIAID: http://www.niaid.nih.gov/dmid/genomes/ - For NIDCR: http://www.nidcr.nih.gov In summary, these conditions are: 1. HIGH PRIORITY SEQUENCING TARGETS. Microorganisms and disease vectors for sequencing have been identified by NIAID or NIDCR as high priority. These priorities will be updated regularly. Applications for large scale sequencing of pathogens or vectors not on this priority list will be returned without review. 2. APPLICATION POLICIES. NIAID/NIDCR policies, including requirement for prior Institute approval and budget guidance, and for submission of applications are met. 3. APPLICATION RECEIPT DATES. Applications may be submitted for the following receipt dates: a. February 1, 2000 for fiscal year 2001 awards. b. February 1, 2001 for fiscal year 2002 awards. c. February 1 annually thereafter. 4. COOPERATIVE AGREEMENTS. Applicants understand and accept terms and conditions to be incorporated in cooperative agreement (U01) awards that will be the funding mechanism for supporting large-scale sequencing projects. 5. PEER REVIEW CONSIDERATIONS. Applications will be peer reviewed by a special review group convened by the NIH Center for Scientific Review (CSR). 6. AWARD CONSIDERATIONS. Only those applications that have received prior approval by the appropriate Institute will be accepted for peer review and consideration for funding. In the event that more than one application proposing to sequence a given organism receives a favorable peer review, only one award will be made. Applicants wishing to apply for support to sequence an organism not found on NIAID"s or NIDCR’s priority lists, must do so in the context of an investigator-initiated, hypothesis-driven research project application (R01), subject to standard NIH acceptance and peer-review procedures. Such applications must contain a substantial research component beyond genome sequencing. INQUIRIES Inquiries concerning this policy are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries to: Dr. Michael Gottlieb Division of Microbiology and Infectious Diseases National Institute of Allergy and Infectious Diseases Room 3102 6700-B Rockledge Drive MSC 7630 Bethesda, MD 20892-7630 Telephone: 301.496.2544 FAX: 301.402.0659 E-mail: mg35s@nih.gov Dr. Dennis F. Mangan Chief, Infectious Diseases Branch Division of Extramural Research National Institute of Dental and Craniofacial Research National Institutes of Health Bldg. 45, Room 4AN-32F Bethesda, MD 20892-6402 Telephone: 301.594.2421 Fax: 301.480.8318 E-mail: Dennis.Mangan@nih.gov

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