NOT-98-097: SEIZURE MODELS TO IDENTIFY NEW COMPOUNDS FOR EPILEPSY

Department of Health
and Human Services (HHS)

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SEIZURE MODELS TO IDENTIFY NEW COMPOUNDS FOR EPILEPSY Release Date: July 15, 1998 REQUEST FOR INFORMATION: NINDS-98-RFI-02 P.T. National Institute of Neurological Disorders and Stroke The National Institute of Neurological Disorders and Stroke (NINDS) is seeking to identify sources who have developed or who have the expertise and capability of developing seizure models, based on current and previous work, that can be used in identifying new chemical entities for the treatment of therapy-resistant epilepsy or recurrent seizures. These seizure models can utilize either in vivo or in vitro technologies. Interested organizations are asked to submit the following information to demonstrate both their organizational and personnel experience and capabilities: 1. For sources who have a seizure model, provide a description of the technology (seizure model) and a summary of the experimental data showing drug effects in the technology. For sources having the expertise and capability of developing a seizure model, provide a description of a proposed model along with supporting evidence of previous experience in developing seizure models. The documentation could be in the form of scientific publications or reports. 2. Provide documentation to demonstrate staff/personnel knowledge, experience and expertise in developing seizure models for drug discovery. 3. Describe the existing animal and laboratory facilities and equipment needed to develop a seizure model. 4. Include other specific and pertinent information as it would pertain to your ability and expertise in this area. Interested organizations should submit a capability statement of approximately 10 pages addressing the information requested above and detailing ability to perform all aspects of the effort described herein. Responses are due by August 19, 1998. Responses will be reviewed only by NIH personnel and will be held in a confidential manner. All proprietary information should be so marked and will be protected. This announcement is a Request for Information (RFI). The purpose of this RFI is to identify potential sources that may be interested and capable of developing new seizure models. The Government does not intend to award a contract on the basis of responses nor otherwise pay for the preparation of any information submitted or the Government"s use of such information. However, should such a requirement materialize, no basis for claims against the Government shall arise as a result of a response to this synopsis or the Government’s use of such information as part of the evaluation process or in developing specifications for any subsequent requirement. This requirement is listed under Standard Industrial Classification SIC Code 8731. All respondents are asked to indicate the type and size of their business organization in their response. INQUIRIES For further information contact: Raina Cervantes National Institute of Neurological Disorders and Stroke 7550 Wisconsin Avenue, Room 901 Bethesda, MD 20892-9190 Telephone: (301) 496-1813 FAX: (301) 402-4225 Email: ec58q@nih.gov

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