COMPETITIVE EXTENSION OF COOPERATIVE AGREEMENT ON THE GENETICS OF ALCOHOLISM, AND AVAILABILITY OF DATA, CELL LINES, AND DNA FROM THIS PROJECT TO THE BROADER RESEARCH COMMUNITY Release Date: May 15, 1998 P.T. National Institute on Alcohol Abuse and Alcoholism PURPOSE The purpose of this notice is to inform the scientific community that a limited number of institutions are being asked to submit applications to recruit additional biological relatives of subjects already enrolled in NIAAA"s Cooperative Agreement on the Genetics of Alcoholism (COGA), and to continue longitudinal tracking of these individuals/families for the purpose of assessing changes in diagnoses. Eligibility is limited to current participants within the Cooperative Agreement on the Genetics of Alcoholism, because of their unique access to the research subjects recruited within the first 10 years of this study. Continued monitoring of subjects in the COGA sample is essential for validation and extension of findings, since newly incident cases of alcoholism can significantly affect the results of linkage analyses. In addition, prospective observation of adolescent subjects bearing presumed predisposing genotypes, as they traverse the period of risk for development of alcoholism, provides a further crucial test of the predictive value of COGA’s linkage findings. Since only investigators with access to subjects already enrolled in the study are able to undertake longitudinal follow-up of these subjects, competition under this Letter of Invitation is being limited to these investigators. Data, DNA, and cell lines generated by COGA prior to September 1, 1999 will be available on September 1, 1999 to all investigators for further studies. Currently, access to data, DNA, and cell lines generated by COGA are available to investigators for protocols which do not directly duplicate studies already ongoing within the COGA project. INQUIRIES For inquiries about the competitive extension of the COGA project, and about access to resources generated by this project, contact Ernestine Vanderveen, Ph.D. Division of Basic Research National Institute on Alcohol Abuse and Alcoholism 6000 Executive Boulevard, Suite 402, MSC 7003 Bethesda, MD 20892-7003 Telephone: (301) 443-2530 FAX: (301) 594-0673 Email: tvanderv@willco.niaaa.nih.gov

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