SBIR and STTR Success Story for
Illumina, Inc.

(Information Posted/Updated on 03/05/2004)

Illumina, Inc.
9885 Towne Centre Drive
San Diego, CA  92121

Contact:    Cynthia Allred
Phone:      858-202-4735
Web Site:

Project Title:  Randomly Ordered Arrays for SNP Genotyping
Related Award(s):  R 44 HG02003
Technology Developed:
The project contributed to the development of BeadLab, a high-throughput system for single nucleotide polymorphism (SNP) genotyping.

Key Words:  polymorphism, SNP, genotyping, genetics, oligonucleotide, fiberoptic, array, multiplex.
Uses of Technology/Products/Service:
The BeadLab technology is used for large-scale genotyping projects for the analysis of genetic variation, such as the International HapMap Project ( A primary use of the technology is to help identify the genetic causes of disease, with the aim of improving diagnosis, management, treatment and prevention of common diseases, and to assist in drug discovery and development. The system is designed not only for generating many genotypes per sample, but also to process many samples accurately, with automated sample tracking and data analysis. The system has been demonstrated to be accurate, robust, high-throughput and cost-effective, and is used by a number of major genomics centers throughout the world. It is also used by Illumina, Inc. as part of its genotyping services operation.

Other Comments Related to Company's Success Story:
The BeadLab system has dramatically reduced genotyping running costs, to less than 5 cents per datapoint. This several-fold decrease over prevailing costs has enabled large-scale projects and, through competition, has helped to drive down the cost of genotyping in the broader marketplace. The economic benefit to the research community has been substantial. For example, NIH has saved many times the cost of this SBIR project in the International HapMap Project alone.

Past R&D and/or Sales from this Project:   $25 million